Lymphocyte Response during Inflammation

Lymphocyte Response during Inflammation

The Beginning of Autoimmune Disorders ...

So when we have necrosis (death of a group of cells), then alarmins are released and the immune system responds.  Now we realize that this can happen from the long-term accumulation of toxins that chemically suffocate and destroy areas of tissue.  It can also happen when our antioxidant reserves are too low to protect cells from free radicals and oxidation.  When we have multiple danger signals, the response can be even greater and longer-lasting.

  • Tissue trauma that doesn't heal
  • Multiple or chronic infections
  • Constipation and the resulting toxicity
  • Radiation or chemotherapy
  • Chronic antibiotic use
  • Poor tissue oxygenation or ischemia
  • Drug use or immunosuppressive side-effects of pharmaceuticals
  • Multiple vaccinations simultaneously or during illness

 

Adaptive Immunity

This is the meat and potatoes of your immune system.  This is what takes over when a challenge to the body extends beyond both the Barrier and Innate immune capabilities.  Adaptive immunity is based on the special properties of the lymph system and specifically lymphocytic cells.  These important T and B cells create a pattern of response that is remembered, an adaptation that allows for a faster, more aggressive response to chronic or future infestations.

This response requires multiple steps including danger signals, antigen presentation, T cell verification and PRRs (Pattern Recognition Receptors).   When cells in the body die, chemicals are released that create alarm signals to the immune system.  For many years it was believed that any cell death would create an immune response.   But we now know that there are immune responses to our own tissues that are a normal, everyday occurrence. 

When a cell dies naturally (apoptosis) then no immune response should be stimulated.  This is partly due to apoptosis occurring to individual cells.  When an entire area of cells dies (necrosis), alarmins are released which are a powerful stimulant to the immune system.  

So our immune system response occur not only as part of"foreign" recognition, but it can also respond to the release of "danger signals", which happen during necrosis. 

"Danger" represents the
ultimate toxin in our body.